Dustin Johnson underwent arthroscopic surgery on Thursday to repair cartilage damage in his left knee.
A statement released by his management team said that Johnson is expected to make a full recovery after the "routine" surgery and will return to competition later this Autumn.
The PGA Tour said that the procedure is similar to the one Johnson had on his right knee in December 2011 to repair cartilage damage.
This is the first indication of any health issues suffered by the former World No.1 this season, who has struggled with his form over the past few months. Johnson won both the Saudi International and WGC Mexico earlier in the year before runner-up finishes in both the Masters and PGA Championship, but hasn't cracked the top 10 since then and finished last in the Tour Championship at East Lake.
The news comes just over a week after it was revealed Tiger Woods had the same type of surgery to repair minor cartilage damage in his left knee.
There is no immediate timetable for Johnson's return.